Mucosal healing in inflammatory bowel disease: impossible ideal or therapeutic target?
نویسندگان
چکیده
منابع مشابه
Assessment of mucosal healing in inflammatory bowel disease: review.
BACKGROUND AND AIMS Mucosal healing is an important treatment end-point in inflammatory bowel disease, and achieving mucosal healing has been demonstrated to improve disease-related outcomes. Considerable uncertainty exists, however, regarding the optimal approach for the assessment of mucosal healing. AIMS To compare currently available diagnostic tools for the assessment of mucosal healing ...
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Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), represents a group of chronic disorders characterized by inflammation of the gastrointestinal tract, typically with a relapsing and remitting clinical course. Cytokines play a key role in the development, recurrence and exacerbation of the inflammatory process in IBD. Advances in the knowledge of ...
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AIM To evaluate circulating IL9 in inflammatory bowel disease and disease-associated anemia/cachexia and assess its potential as a mucosal healing marker. METHODS Serum IL9 as well as other cytokines (IL1β, IL6, IL13, IFNγ, TNFα, and VEGF-A) were determined in 293 individuals: 97 patients with Crohn's disease (CD) and 74 with ulcerative colitis (UC) and in 122 apparently healthy controls. The...
متن کاملAssociation of sleep quality and mucosal healing in patients with inflammatory bowel disease in clinical remission
Background The interaction between sleep and the immune system has been increasingly studied over the last decades. The aim of this study was to investigate the association between sleep quality and mucosal healing in patients with inflammatory bowel disease (IBD) currently in clinical remission. Methods Ninety patients with IBD in clinical remission were studied: 54 (60%) with Crohn's diseas...
متن کاملCurrent and Future Targets for Mucosal Healing in Inflammatory Bowel Disease.
The induction and subsequent maintenance of mucosal healing has emerged as one of the central therapeutic goals in the management of patients with inflammatory bowel disease (IBD) (Crohn's disease and ulcerative colitis). Current and novel treatment options are assessed regarding their therapeutic efficacy on the basis of their ability to induce mucosal healing. However, there is still substant...
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ژورنال
عنوان ژورنال: Gut
سال: 2007
ISSN: 0017-5749
DOI: 10.1136/gut.2005.088732